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CAS NO.555-30-6
| Methyldopa Basic information |
| Product Name: | Methyldopa |
| Synonyms: | MK-351;L-(-)-ALPHA-METHYLDOPA;L-ALPHA-METHYL-DOPA;L-3-(3,4-DIHYDROXYPHENYL)-2-METHYLALANINE;MEDOBA;L-METHYLDOPA;METHYL DOPA;METHYL-L-DOPA |
| CAS: | 555-30-6 |
| MF: | C10H13NO4 |
| MW: | 211.21 |
| EINECS: | 209-089-2 |
| Product Categories: | API's;Aldomet;RUBRAMIN |
| Mol File: | 555-30-6.mol |
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| Methyldopa Chemical Properties |
| mp | ≥300 °C |
| refractive index | -14 ° (C=1, H2O) |
| storage temp. | Store at RT |
| Merck | 6055 |
| CAS DataBase Reference | 555-30-6(CAS DataBase Reference) |
| EPA Substance Registry System | L-Tyrosine, 3-hydroxy-.alpha.-methyl-(555-30-6) |
| Safety Information |
| WGK Germany | 3 |
| RTECS | YP2860000 |
| F | 10-23 |
| Hazardous Substances Data | 555-30-6(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 2-Amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid | English |
| SigmaAldrich | English |
| Methyldopa Usage And Synthesis |
| Usage | Antihypertensor;L-aromatic aminoacid decarboxylase inhibitor |
| Usage | vitamin, coenzyme B12 |
| General Description | Colorless or almost colorless crystals or white to yellowish-white fine powder. Almost tasteless. In the sesquihydrate form. pH (saturated aqueous solution) about 5.0. |
| Air & Water Reactions | Very hygroscopic. Slightly water soluble. May be sensitive to prolonged exposure to air and light. The stability of aqueous solutions is markedly dependent on pH, oxygen and the amount of initial reactant. Aqueous solutions are stable for up to 50 hours in acid and neutral pH (6.2). At pH 8.0, decomposition products are formed in 3 to 5 hours. Solutions develop a red tint that becomes progressively darker (eventually forming a black precipitate). |
| Reactivity Profile | Methyldopa undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions . A weakly acidic amino acid. |
| Fire Hazard | Flash point data for Methyldopa are not available; however, Methyldopa is probably combustible. |
| Biological Activity | L-aromatic amino acid decarboxylase inhibitor. Antihypertensive. |
| Methyldopa Preparation Products And Raw materials |
| Raw materials | Dimethyl sulfate-->Vanillin-->Anisole-->Nitroethane-->Veratraldehyde-->3,4-Dimethoxyphenylacetone-->3-Hydroxy-alpha-methyl-DL-tyrosine |
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