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CAS NO.54-85-3
1(10-100)Metric Ton1(10-100)Metric Ton
| Isoniazid Basic information |
| Product Name: | Isoniazid |
| Synonyms: | 4-PYRIDINECARBOHYDRAZIDE;4-PYRIDINECARBOXYLIC ACID HYDRAZIDE;AKOS BBS-00004103;HYCOZID;LABOTEST-BB LT00146690;INAH;ISONICOTINIC ACID HYDRAZIDE;ISONIAZIDE |
| CAS: | 54-85-3 |
| MF: | C6H7N3O |
| MW: | 137.14 |
| EINECS: | 200-214-6 |
| Product Categories: | AMIDE;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;NYDRAZID;Antituberculotic;API |
| Mol File: | 54-85-3.mol |
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| Isoniazid Chemical Properties |
| mp | 171-173 °C(lit.) |
| Fp | >250°C |
| storage temp. | Refrigerator |
| Water Solubility | 14 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive |
| Merck | 14,5186 |
| BRN | 119374 |
| Stability: | Stability Stable, but may be air or light sensitive. Combustible. Incompatible with strong oxidizing agents, chloral, aldehydes, iodine, ferric salts, hypochlorites. |
| CAS DataBase Reference | 54-85-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Isoniazid(54-85-3) |
| EPA Substance Registry System | 4-Pyridinecarboxylic acid, hydrazide(54-85-3) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-38-40-36/37/38 |
| Safety Statements | 37-36/37/39-26 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | NS1751850 |
| PackingGroup | III |
| HS Code | 29333999 |
| Hazardous Substances Data | 54-85-3(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| INAH | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Isoniazid Usage And Synthesis |
| Chemical Properties | white crystalline powder |
| Usage | antibacterial, tuberculostatic |
| Usage | Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Sele ctively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antib acterial (tuberculostatic). |
| Usage | For the treatment of all forms of tuberculosis in which organisms are susceptible. |
| General Description | Odorless colorless or white crystals or white crystalline powder. Taste is slightly sweet at first and then bitter. pH (1% aqueous solution) 5.5-6.5. pH (5% aqueous solution) 6-8. |
| Air & Water Reactions | Sensitive to air and light. Absorbs insignificant amounts of moisture at 77°F at relative humidities up to approximately 90%. Water soluble. Dust can be explosive when suspended in air at specific concentrations. |
| Reactivity Profile | Isoniazid is incompatible with chloral, aldehydes, iodine, hypochlorites and ferric salts. Isoniazid is also incompatible with oxidizers. Isoniazid may react with sugars and ketones. Isoniazid can react as a weak acid or a weak base. Isoniazid can be decomposed by oxidative and reductive reactions. |
| Fire Hazard | Isoniazid is combustible. |
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