HENAN SUNLAKE ENTERPRISE CORPORATION
Free supplier Enterprise Certification
- Free
supplier - 9th
years
Free supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
MaxCard:
Contact Suppliers
CAS NO.54-31-9
| Furosemide Basic information |
| Product Name: | Furosemide |
| Synonyms: | LABOTEST-BB LT00244801;FUROSEMID;FUROSEMIDE;FRUSEMIDE;2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid;4-CHLORO-N-FURFURYL-5-SULFAMOYLANTHRANILIC ACID;5-(AMINOSULPHONYL)-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID;5-[AMINOSULFONYL]-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID |
| CAS: | 54-31-9 |
| MF: | C12H11ClN2O5S |
| MW: | 330.74 |
| EINECS: | 200-203-6 |
| Product Categories: | Organics;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Ion transporter and other ion channel;GABA;Aromatics;Heterocycles;Sulfur & Selenium Compounds;API;LASIX;Other APIs |
| Mol File: | 54-31-9.mol |
|
|
|
| Furosemide Chemical Properties |
| mp | 220 °C (dec.)(lit.) |
| density | 1.606 |
| Fp | 11 °C |
| storage temp. | 2-8°C |
| Merck | 4309 |
| Stability: | Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 54-31-9(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 5-(aminosulfonyl)-4-chloro- 2-((2-furanylmethyl)amino)- (54-31-9) |
| Safety Information |
| Hazard Codes | T,F,Xi |
| Risk Statements | 61-39/23/24/25-23/24/25-11-36/37/38 |
| Safety Statements | 7-16-36/37-45-53-36/37/39-22-36-26 |
| RIDADR | UN 1230 3/PG 2 |
| WGK Germany | 3 |
| RTECS | CB2625000 |
| Hazardous Substances Data | 54-31-9(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid | English |
| SigmaAldrich | English |
| Furosemide Usage And Synthesis |
| Efficient diuretics |
Furosemide, is a class of efficient sulfonamide diuretics acting on the medullary loop of the ascending branch of the medulla,it has a strong and short-term diuretic effect,which can increase the excretion of water, sodium, chloride, potassium, calcium, magnesium, phosphate and so on. It Mainly inhibits Na + and Cl- reabsorption in medullary and cortex of the medullary loop ascending branch crude segment , it can promote the excretion of sodium, chloride and potassium and affect the formation of renal medullary high osmotic pressure,it can interfer the process of concentration and dilution of urine, and it can increase urine output. This product can inhibit the activity of prostaglandin decomposition enzyme ,make the content of prostaglandin E2 increase,it has effect on expansion of blood vessels, it also plays a role in the proximal tubule, glomerular filtration,it can increase renal blood flow,and adjust renal blood flow distribution,and reduce blood flow so that the cortex surface blood flow increases,it promotes diuresis, its effect is fast and strong, it is used for other diuretics invalid cases. Clinically it is used for the treatment of cardiac edema, renal edema, cirrhosis ascitic fluid, peripheral edema caused by dysfunction or vascular disorders , and it may contribute to an upper urinary tract stones excretion. Administration intravenously can treat brain edema, it also can accelerate the excretion of toxic substances in cerebral edema in poisoning . Note that when the diuretic furosemide is used, since the excretion of urine Cl-, Na +, K +, H + is increasing, while the excretion of HCO3- is not increasing, long-term repeated drug use or large quantities of drugs can cause low salt syndrome, low chlorine and low potassium alkalosis. In recent years, researchers find that inhalation of furosemide can have a significant effect on asthma, it is like cromolyn sodium, which through inhibition of allergic mediator release, it can inhibit the release of the neurotransmitter acetylcholine and substance P, which may be related to inhibiting chloride ions into the cell membranes of respiratory tract. Clinically,it is used in exercise-induced asthma, immediate and delayed type antigen-induced asthma. The above information is edited by the Chemicalbook of Tian Ye. |
| Chemical properties | white or white alike crystalline powder. 206 ℃ melting point. Dissolved in acetone, methanol, dimethyl formamide, slightly soluble in ethanol, insoluble in water. Odorless, almost tasteless. |
| Application | The diuretic effect of this product is a strong and short,it is a potent diuretic for the treatment of edema caused by heart, liver, kidney and other diseases, in particular, the base cases which other diuretics are invalid to;it can be used to treat acute pulmonary edema, brain edema , acute renal failure and high blood pressure and other diseases; in combination with fluid infusion, the product can promote poison excretion. Rat oral LD50 is 2600-2820mg / kg. |
| production method | 2,4-dichlorobenzoic acid (see 12740) by sulfochlorination,ammoniation, acidification ,dichloro-5-sulfamoyl-benzoic acid is obtained. Then after condensation with the chaff amine , furosemide is produced. |
| Category | Toxic substances |
| Toxicity grading | Middle toxic |
| Acute toxicity | Oral - rat LD50: 2600 mg / kg; Oral - Mouse LD50: 2200 mg / kg. |
| Flammability and hazard characteristics | Combustible; fire decomposition produces toxic nitrogen oxides; sulfur oxides and chlorides smoke. |
| Storage Characteristics | Ventilated, low-temperature ,dry storeroom. |
| Extinguishing agent | Water, carbon dioxide, dry powder,sandy soil. |
| Chemical Properties | white to light yellow crystal powde |
| Usage | diuretic, antihypertensive |
| Usage | Furosemide inhibits ion co-transport in the kidney. Furosemide is used as a diuretic. |
| Usage | This compound belongs to the aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring. |
| General Description | Odorless white to slightly yellow crystalline powder. A diuretic drug. Almost tasteless. |
| Air & Water Reactions | Light sensitive. Air sensitive. Slightly soluble in water. |
| Reactivity Profile | Furosemide may undergo hydrolysis at sufficiently low pH. The pH of aqueous solutions should be maintained in the basic range to prevent hydrolysis. Alcohol has been shown to improve the stability of Furosemide. Incompatible with strong oxidizing agents . |
| Fire Hazard | Flash point data for Furosemide are not available; however, Furosemide is probably combustible. |
| Biological Activity | Loop diuretic that inhibits the Na + /2Cl - /K + (NKCC) cotransporter. Also acts as a non-competitive antagonist at GABA A receptors with ~ 100-fold greater selectivity for α 6-containing receptors than α 1-containing receptors. |
| Furosemide Preparation Products And Raw materials |
| Raw materials | 2,4-Dichlorobenzoic acid-->2,4-Dichloro-5-sulfamoylbenzoic acid-->Furfurylamine |
Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others. These products have been being well exported to Europe, Southeast Asia, the Middle East ,Africa, South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team. We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market.
We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!