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51333-22-3 C25H34O6 Budesonide

CAS NO.51333-22-3

  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,Other
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Product Details

Keywords

  • 51333-22-3 PREFERID
  • 51333-22-3 PULMICORT
  • C25H34O6 TBIDIEN

Quick Details

  • ProName: 51333-22-3 C25H34O6 Budesonide
  • CasNo: 51333-22-3
  • Molecular Formula: C25H34O6
  • Appearance: White Solid
  • Application: 51333-22-3
  • DeliveryTime: 7-10 days after payment
  • PackAge: As customer's requirment
  • Port: China main port
  • ProductionCapacity: 100-200 Kilogram/Month
  • Purity: 99%
  • Storage: Store at RT
  • Transportation: By air or sea or express
  • LimitNum: 1 Kilogram

Superiority

Product Name: Budesonide
Synonyms: PREFERID;PULMICORT;SPIROCORT;S-1320;RHINOCORT;BIDIEN;BUDESONIDE;CORTIVENT
CAS: 51333-22-3
MF: C25H34O6
MW: 430.53
EINECS: 257-139-7
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;CASAKOL;Inhibitors
Mol File: 51333-22-3.mol
Budesonide Structure
 
Budesonide Chemical Properties
mp  221-232°C (dec.)
storage temp.  Store at RT
CAS DataBase Reference 51333-22-3(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xn
Risk Statements  40-36/37/38-20/21/22
Safety Statements  22-36-26
WGK Germany  3
RTECS  TU3723000
HS Code  29372900
 
Budesonide Usage And Synthesis
Drugs for Treatment of asthma Budesonide is a commonly used in the treatment of bronchial asthma clinical drug in China.it can be used for non-hormone-dependent or hormone-dependent asthma, and chronic asthmatic bronchitis. Or it is used for the treatment of seasonal allergic rhinitis and many years occurring allergic rhinitis and it is used for preventing polyps regeneration after the removal of nasal polyps . It can also be used to treat various skin diseases. 
Budesonide is a halogen-free, topically applied , adrenal corticosteroid,it has significant anti-inflammatory, anti-allergic, anti-itching and anti-exudative effects. Its local effects is the same as beclomethasone dipropionate , it is mainly used for bronchial asthma which in the past bronchodilator or an antiallergic agent can not well control. This product can relieve bronchial spasm, pulmonary inhalation has anti-inflammatory effects, long-term use is well tolerated, it can reduce oral glucocorticoid dosage, without systemic effects of corticosteroids. It has the same effect on Children and adults with asthma as beclomethasone dipropionate , it has good effect, and it can be tolerated in long-term use ,for glucocorticoid-dependent or glucocorticoid-independent patients, mist inhaled can control asthma attacks and can effectively relapse prevention, inhaled treatment for 3 to 6 months, improvement in lung function is shown,the number of acute episodes is reduced , recoverability of plasma corticosterone concentration is gradually increased, and the daily dose of oral corticosteroids can be reduced by 40% to 50%. Thus,for glucocorticoid-dependent asthma patients, especially in patients with a larger amount of dose,the product can be used as an ideal alternative to thedrug for oral administration. Glucocorticoid effects of budesonide are strong, but mineralocorticoid effects are weak . Animal tests show that the drug’s effects on glucocorticoid receptor affinity are 200 times of cortisone, anti-inflammatory effects when it is applied topically are 1,000 times of cortisone , and subcutaneous and oral anti-inflammatory effects are only 40 and 25 times stronger than cortisone .
Clinical evaluation The Huashan Hospital, Shanghai Second Medical University Renji Hospital, Xinhua Hospital have clinically proven this product for treatment of bronchial asthma. Choose 60 cases of bronchial asthma at the age of 18 to 65, light and moderate non-acute exacerbation , inhalation of 400μg, bid, continuous medication for 4 weeks. After 4 weeks of treatment, results showed that inhaled budesonide for the treatment of bronchial asthma, could have exact clinical efficacy on controlling wheeze, wheezing and coughing , its wheeze disappearance rate was 83.3%, and the patient's pulmonary function ( including FVC, FEV1) was significantly improved, but also other asthma drugs (eg, theophylline, albuterol, etc.) used was significantly reduced . After using this product ,2% of patients had occurred sore throat, but the symptoms are mild, and liver and kidney function, blood, urine, ECG and plasma cortisol were not affected. Domestic and international data show that budesonide efficacy and safety were superior to beclomethasone and albuterol.
Precaution and Inhibition Take Caution when it is used in tuberculosis, airway fungal infection or viral infection. Avoid pregnancy administration. Oral steroid-dependent patients, should gradually reduce oral steroid dose after 10d use , until it reaches a stable respiratory capacity minimum. In severe stress, the dose of oral steroids should be increased, such as severe infection, trauma, surgery. When sputum thickens and congests the airway , the short-term oral steroid should be supplemented . Fast Reduction of Oral hormone, can cause withdrawal symptoms, such as arthritis, rhinitis, eczema, muscle and joint pain,which should be paid attention to prevent it. 
Budesonide can be used for mild asthma, when asthma symptoms are obvious,they should be added with a larger dose of water-soluble corticosteroids or bronchodilators and antihistamines. Aerosol has throat irritation on individual patient , Candida albicans infections may occur , rinse mouth and throat immediately after inhalation which can reduce irritation.
The above information is edited by the chemicalbook of Tian Ye.
Application for the treatment of skin diseases, asthma and other illnesses.
Category Toxic substances
Toxicity grading Middle toxic
Acute toxicity intraperitoneal - rat LD50: 138 mg / kg; Oral - Mouse LD50: 4750 mg / kg.
Flammability and hazard characteristics It produces toxic fumes spicy and stimulating through thermal decomposition.
Storage Characteristics Ventilated, low-temperature ,dry storeroom.
Extinguishing agent Water, powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.
Chemical Properties White Solid
Usage A non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent
Usage laxative, antineoplastic
Usage The oral capsule is used for the treatment of mild to moderate active Crohn's disease. The oral tablet is used for induction of remission in patients with active, mild to moderate ulcerative colitis. The oral inhalation formulation is used for the treatme
Biological Activity Synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.
 
Budesonide Preparation Products And Raw materials

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Details

Product Name: Budesonide
Synonyms: PREFERID;PULMICORT;SPIROCORT;S-1320;RHINOCORT;BIDIEN;BUDESONIDE;CORTIVENT
CAS: 51333-22-3
MF: C25H34O6
MW: 430.53
EINECS: 257-139-7
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;CASAKOL;Inhibitors
Mol File: 51333-22-3.mol
Budesonide Structure
 
Budesonide Chemical Properties
mp  221-232°C (dec.)
storage temp.  Store at RT
CAS DataBase Reference 51333-22-3(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xn
Risk Statements  40-36/37/38-20/21/22
Safety Statements  22-36-26
WGK Germany  3
RTECS  TU3723000
HS Code  29372900
 
Budesonide Usage And Synthesis
Drugs for Treatment of asthma Budesonide is a commonly used in the treatment of bronchial asthma clinical drug in China.it can be used for non-hormone-dependent or hormone-dependent asthma, and chronic asthmatic bronchitis. Or it is used for the treatment of seasonal allergic rhinitis and many years occurring allergic rhinitis and it is used for preventing polyps regeneration after the removal of nasal polyps . It can also be used to treat various skin diseases. 
Budesonide is a halogen-free, topically applied , adrenal corticosteroid,it has significant anti-inflammatory, anti-allergic, anti-itching and anti-exudative effects. Its local effects is the same as beclomethasone dipropionate , it is mainly used for bronchial asthma which in the past bronchodilator or an antiallergic agent can not well control. This product can relieve bronchial spasm, pulmonary inhalation has anti-inflammatory effects, long-term use is well tolerated, it can reduce oral glucocorticoid dosage, without systemic effects of corticosteroids. It has the same effect on Children and adults with asthma as beclomethasone dipropionate , it has good effect, and it can be tolerated in long-term use ,for glucocorticoid-dependent or glucocorticoid-independent patients, mist inhaled can control asthma attacks and can effectively relapse prevention, inhaled treatment for 3 to 6 months, improvement in lung function is shown,the number of acute episodes is reduced , recoverability of plasma corticosterone concentration is gradually increased, and the daily dose of oral corticosteroids can be reduced by 40% to 50%. Thus,for glucocorticoid-dependent asthma patients, especially in patients with a larger amount of dose,the product can be used as an ideal alternative to thedrug for oral administration. Glucocorticoid effects of budesonide are strong, but mineralocorticoid effects are weak . Animal tests show that the drug’s effects on glucocorticoid receptor affinity are 200 times of cortisone, anti-inflammatory effects when it is applied topically are 1,000 times of cortisone , and subcutaneous and oral anti-inflammatory effects are only 40 and 25 times stronger than cortisone .
Clinical evaluation The Huashan Hospital, Shanghai Second Medical University Renji Hospital, Xinhua Hospital have clinically proven this product for treatment of bronchial asthma. Choose 60 cases of bronchial asthma at the age of 18 to 65, light and moderate non-acute exacerbation , inhalation of 400μg, bid, continuous medication for 4 weeks. After 4 weeks of treatment, results showed that inhaled budesonide for the treatment of bronchial asthma, could have exact clinical efficacy on controlling wheeze, wheezing and coughing , its wheeze disappearance rate was 83.3%, and the patient's pulmonary function ( including FVC, FEV1) was significantly improved, but also other asthma drugs (eg, theophylline, albuterol, etc.) used was significantly reduced . After using this product ,2% of patients had occurred sore throat, but the symptoms are mild, and liver and kidney function, blood, urine, ECG and plasma cortisol were not affected. Domestic and international data show that budesonide efficacy and safety were superior to beclomethasone and albuterol.
Precaution and Inhibition Take Caution when it is used in tuberculosis, airway fungal infection or viral infection. Avoid pregnancy administration. Oral steroid-dependent patients, should gradually reduce oral steroid dose after 10d use , until it reaches a stable respiratory capacity minimum. In severe stress, the dose of oral steroids should be increased, such as severe infection, trauma, surgery. When sputum thickens and congests the airway , the short-term oral steroid should be supplemented . Fast Reduction of Oral hormone, can cause withdrawal symptoms, such as arthritis, rhinitis, eczema, muscle and joint pain,which should be paid attention to prevent it. 
Budesonide can be used for mild asthma, when asthma symptoms are obvious,they should be added with a larger dose of water-soluble corticosteroids or bronchodilators and antihistamines. Aerosol has throat irritation on individual patient , Candida albicans infections may occur , rinse mouth and throat immediately after inhalation which can reduce irritation.
The above information is edited by the chemicalbook of Tian Ye.
Application for the treatment of skin diseases, asthma and other illnesses.
Category Toxic substances
Toxicity grading Middle toxic
Acute toxicity intraperitoneal - rat LD50: 138 mg / kg; Oral - Mouse LD50: 4750 mg / kg.
Flammability and hazard characteristics It produces toxic fumes spicy and stimulating through thermal decomposition.
Storage Characteristics Ventilated, low-temperature ,dry storeroom.
Extinguishing agent Water, powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.
Chemical Properties White Solid
Usage A non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent
Usage laxative, antineoplastic
Usage The oral capsule is used for the treatment of mild to moderate active Crohn's disease. The oral tablet is used for induction of remission in patients with active, mild to moderate ulcerative colitis. The oral inhalation formulation is used for the treatme
Biological Activity Synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.
 
Budesonide Preparation Products And Raw materials

 

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