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CAS NO.50847-11-5
| Product Name: | Ibudilast |
| Synonyms: | IBUDILAST;IBUDILAST-D7;KC-404;1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL];2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine;2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE;3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE;2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon |
| CAS: | 50847-11-5 |
| MF: | C14H18N2O |
| MW: | 230.31 |
| EINECS: | |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Cyclic Nucleotide related;Amines;Heterocycles;Inhibitors |
| Mol File: | 50847-11-5.mol |
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| Ibudilast Chemical Properties |
| mp | 53-54°C |
| density | 1.09 |
| storage temp. | 2-8°C |
| solubility | DMSO: 28 mg/mL, soluble |
| form | solid |
| color | white |
| CAS DataBase Reference | 50847-11-5(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | UR0711200 |
| MSDS Information |
| Provider | Language |
|---|---|
| 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone | English |
| SigmaAldrich | English |
| Ibudilast Usage And Synthesis |
| Chemical Properties | White Solid |
| Usage | a phosphodiesterase inhibitor with anti-inflammatory activity |
| Usage | A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral) |
| Biological Activity | Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent. |
| Ibudilast Preparation Products And Raw materials |
| Raw materials | Sodium acetate-->2-Picoline-->Isobutyric anhydride |
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| Product Name: | Ibudilast |
| Synonyms: | IBUDILAST;IBUDILAST-D7;KC-404;1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL];2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine;2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE;3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE;2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon |
| CAS: | 50847-11-5 |
| MF: | C14H18N2O |
| MW: | 230.31 |
| EINECS: | |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Cyclic Nucleotide related;Amines;Heterocycles;Inhibitors |
| Mol File: | 50847-11-5.mol |
|
|
|
| Ibudilast Chemical Properties |
| mp | 53-54°C |
| density | 1.09 |
| storage temp. | 2-8°C |
| solubility | DMSO: 28 mg/mL, soluble |
| form | solid |
| color | white |
| CAS DataBase Reference | 50847-11-5(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | UR0711200 |
| MSDS Information |
| Provider | Language |
|---|---|
| 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone | English |
| SigmaAldrich | English |
| Ibudilast Usage And Synthesis |
| Chemical Properties | White Solid |
| Usage | a phosphodiesterase inhibitor with anti-inflammatory activity |
| Usage | A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral) |
| Biological Activity | Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent. |
| Ibudilast Preparation Products And Raw materials |
| Raw materials | Sodium acetate-->2-Picoline-->Isobutyric anhydride |