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CAS NO.43210-67-9
1(10-100)Kilogram1(100-500)Kilogram2(500-1000)Kilogram
1. Certificate Of Analysis (COA)
2. Material Safety Data Sheet (MSDS)
3. Route of synthesis (ROS)
4. Method of Aanlysis (MOA)
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| Fenbendazole Basic information |
| Benzimidazole anthelmintics Aofendazuo Chemical Properties Application Production method |
| Product Name: | Fenbendazole |
| Synonyms: | [5-(PHENYLTHIO)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER;HOE-881V;FENBENDAZOLE;METHYL 5-(PHENYLTHIO)-2-BENZIMIDAZOLECARBAMATE;SAFEGARD;PANACUR;(5-(phenylthio)-1h-benzimidazol-2-yl)-carbamicacimethylester;5-(phenylthio)-2-benzimidazolecarbamicacimethylester |
| CAS: | 43210-67-9 |
| MF: | C15H13N3O2S |
| MW: | 299.35 |
| EINECS: | 256-145-7 |
| Product Categories: | PHARMACEUTICALS;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries;Amines;Aromatics;Heterocycles;Sulfur & Selenium Compounds;ProteasomeInhibitors;PANACUR;Other APIs;vermifuge |
| Mol File: | 43210-67-9.mol |
|
|
|
| Fenbendazole Chemical Properties |
| mp | 233°C |
| storage temp. | 0-6°C |
| CAS DataBase Reference | 43210-67-9(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 2 |
| RTECS | DD6520500 |
| MSDS Information |
| Provider | Language |
|---|---|
| [5-(phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester | English |
| SigmaAldrich | English |
| Fenbendazole Usage And Synthesis |
| Benzimidazole anthelmintics |
Fenbendazole is a benzimidazole anthelmintic with a broad spectrum,high efficiency and low toxicity ,in the structure,it has a strong affinity with the parasite tubulin ,by influencing cell transport and energy metabolism,it plays a role in preventing the polymerization of micro tubes, which ultimately destroys the integrity of parasite cells and energy transmission. Fenbendazole is used to drive and to kill the animal gastrointestinal parasites, it not only has a highly anthelmintic activity on animal gastrointestinal roundworms, hookworms, whipworms, some tapeworms and nematodes , but also has a preferred effect on the part of the bronchial tree and lung parasites (Aelurostrongylus abstrutus and lung fluke) . |
| Aofendazuo |
Aofendazuo is a benzimidazole anthelmintic, also known as the Austrian phenol metronidazole, oxfendazole, benzene etomidate sulfoxide, benzene sulfur oxygen imidazole ,it is the sulfoxide form of Fenbendazole , white or off-white powder at room temperature, slight special smell, it can damage the microtubules of the worms epithelial cells of the gastrointestinal tract, and inhibit the worms uptake of glucose from the intestine. Aofendazuo is used for the treatment and control of gastrointestinal adults and larvae, it has a good effect on the treatment of in vivo roundworms and lung worms in pigs and sheep , including Oster nematodes (Ostertagia), Haemonchus , Trichostrongylus, Nematodirus , Cooper nematode (Cooperia), capillary nematodes (Capillaria), toothed Oesophagostomum (Oesophagostomum), Chabertia, Trichuris nematodes form (Trichuris) and dictyocaulasis ( Dictyocaulus) and so on. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | Gray light brown crystalline powder. Melting point 233 ℃ (decomposition). Soluble in dimethyl sulfoxide (DMSO), slightly soluble in common organic solvents, insoluble in water. Odorless, tasteless. |
| Application | Anthelmintic. Broad-spectrum, high efficiency, low toxicity, antiparasitic. It has a strong killing effect on Roundworm, nematodes, tapeworms, cysticercosis , Fasciola and other parasites, not only killing worms, especially having a great effect on Transitional larvae ehich are hazardous to the liver, lungs and intestines .Fenbendazole is a benzimidazole anthelmintic, not only having a highly anthelmintic activity for gastrointestinal nematodes adults and larvae , but also having a good effect on dictyocaulasis, flukes and tapeworms, in addition,it has a strong killing eggs effect. |
| Production method | 5-chloro-2-nitroaniline reacts with benzene thiol, to thereby obtain 5-phenylthio-2-nitroaniline in 91% yield.Generate 3-phenylthio-o-phenylenediamine by ferrous sulfate - iron reduction in 90% yield. Finally, cyclize it with the S- methyl - melamine Methyl to obtain fenbendazole. |
| Chemical Properties | Off-White Solid |
| Usage | An anthelmintic (Nematodes) |
| Fenbendazole Preparation Products And Raw materials |
| Preparation Products | Oxfendazole |
| Raw materials | Chloroform-->Acetonitrile-->Iron-->o-Phenylenediamine-->3-Chloroaniline-->Thiophenol-->5-Chloro-2-nitroaniline-->5-PHENYLTHIO-2-NITROANILINE |
| Fenbendazole Basic information |
| Benzimidazole anthelmintics Aofendazuo Chemical Properties Application Production method |
| Product Name: | Fenbendazole |
| Synonyms: | [5-(PHENYLTHIO)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER;HOE-881V;FENBENDAZOLE;METHYL 5-(PHENYLTHIO)-2-BENZIMIDAZOLECARBAMATE;SAFEGARD;PANACUR;(5-(phenylthio)-1h-benzimidazol-2-yl)-carbamicacimethylester;5-(phenylthio)-2-benzimidazolecarbamicacimethylester |
| CAS: | 43210-67-9 |
| MF: | C15H13N3O2S |
| MW: | 299.35 |
| EINECS: | 256-145-7 |
| Product Categories: | PHARMACEUTICALS;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries;Amines;Aromatics;Heterocycles;Sulfur & Selenium Compounds;ProteasomeInhibitors;PANACUR;Other APIs;vermifuge |
| Mol File: | 43210-67-9.mol |
|
|
|
| Fenbendazole Chemical Properties |
| mp | 233°C |
| storage temp. | 0-6°C |
| CAS DataBase Reference | 43210-67-9(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 2 |
| RTECS | DD6520500 |
| MSDS Information |
| Provider | Language |
|---|---|
| [5-(phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester | English |
| SigmaAldrich | English |
| Fenbendazole Usage And Synthesis |
| Benzimidazole anthelmintics |
Fenbendazole is a benzimidazole anthelmintic with a broad spectrum,high efficiency and low toxicity ,in the structure,it has a strong affinity with the parasite tubulin ,by influencing cell transport and energy metabolism,it plays a role in preventing the polymerization of micro tubes, which ultimately destroys the integrity of parasite cells and energy transmission. Fenbendazole is used to drive and to kill the animal gastrointestinal parasites, it not only has a highly anthelmintic activity on animal gastrointestinal roundworms, hookworms, whipworms, some tapeworms and nematodes , but also has a preferred effect on the part of the bronchial tree and lung parasites (Aelurostrongylus abstrutus and lung fluke) . |
| Aofendazuo |
Aofendazuo is a benzimidazole anthelmintic, also known as the Austrian phenol metronidazole, oxfendazole, benzene etomidate sulfoxide, benzene sulfur oxygen imidazole ,it is the sulfoxide form of Fenbendazole , white or off-white powder at room temperature, slight special smell, it can damage the microtubules of the worms epithelial cells of the gastrointestinal tract, and inhibit the worms uptake of glucose from the intestine. Aofendazuo is used for the treatment and control of gastrointestinal adults and larvae, it has a good effect on the treatment of in vivo roundworms and lung worms in pigs and sheep , including Oster nematodes (Ostertagia), Haemonchus , Trichostrongylus, Nematodirus , Cooper nematode (Cooperia), capillary nematodes (Capillaria), toothed Oesophagostomum (Oesophagostomum), Chabertia, Trichuris nematodes form (Trichuris) and dictyocaulasis ( Dictyocaulus) and so on. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | Gray light brown crystalline powder. Melting point 233 ℃ (decomposition). Soluble in dimethyl sulfoxide (DMSO), slightly soluble in common organic solvents, insoluble in water. Odorless, tasteless. |
| Application | Anthelmintic. Broad-spectrum, high efficiency, low toxicity, antiparasitic. It has a strong killing effect on Roundworm, nematodes, tapeworms, cysticercosis , Fasciola and other parasites, not only killing worms, especially having a great effect on Transitional larvae ehich are hazardous to the liver, lungs and intestines .Fenbendazole is a benzimidazole anthelmintic, not only having a highly anthelmintic activity for gastrointestinal nematodes adults and larvae , but also having a good effect on dictyocaulasis, flukes and tapeworms, in addition,it has a strong killing eggs effect. |
| Production method | 5-chloro-2-nitroaniline reacts with benzene thiol, to thereby obtain 5-phenylthio-2-nitroaniline in 91% yield.Generate 3-phenylthio-o-phenylenediamine by ferrous sulfate - iron reduction in 90% yield. Finally, cyclize it with the S- methyl - melamine Methyl to obtain fenbendazole. |
| Chemical Properties | Off-White Solid |
| Usage | An anthelmintic (Nematodes) |
| Fenbendazole Preparation Products And Raw materials |
| Preparation Products | Oxfendazole |
| Raw materials | Chloroform-->Acetonitrile-->Iron-->o-Phenylenediamine-->3-Chloroaniline-->Thiophenol-->5-Chloro-2-nitroaniline-->5-PHENYLTHIO-2-NITROANILINE |