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CAS NO.378-44-9
1(10-100)Kilogram1(100-500)Kilogram2(500-1000)Kilogram
1. Certificate Of Analysis (COA)
2. Material Safety Data Sheet (MSDS)
3. Route of synthesis (ROS)
4. Method of Aanlysis (MOA)
5. Nuclear Magnetic Resonance (NMR)
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| Product Name: | Betamethasone |
| Synonyms: | (11beta,16beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;16-beta-methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20;16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione;17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-9-alpha-fluoro-11-bet;6beta)-;9-alpha-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione;9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-beta-methylpregna-1,4-diene;9-alpha-fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20 |
| CAS: | 378-44-9 |
| MF: | C22H29FO5 |
| MW: | 392.46 |
| EINECS: | 206-825-4 |
| Product Categories: | Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;Pharmaceutical intermediate;CELESTONE |
| Mol File: | 378-44-9.mol |
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|
|
| Betamethasone Chemical Properties |
| mp | 235-237°C |
| refractive index | 118 ° (C=1, Dioxane) |
| storage temp. | 0-6°C |
| Merck | 1180 |
| CAS DataBase Reference | 378-44-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-(378-44-9) |
| Safety Information |
| Hazard Codes | Xi,Xn,T |
| Risk Statements | 40-48/20/21-61 |
| Safety Statements | 22-36-45-53 |
| RTECS | TU4000000 |
| HS Code | 29379000 |
| Hazardous Substances Data | 378-44-9(Hazardous Substances Data) |
| Betamethasone Usage And Synthesis |
| hormone drugs |
Betamethasone, belongs to adrenal corticosteroids, it is a isomer of dexamethasone , and the role of betamethasone is similiar to prednisolone and dexamethasone , it has anti-inflammatory, anti-rheumatic, anti-allergic and suppression of the immune and other pharmacological effects, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone etc. , it can reduce and prevent tissue response to inflammation and eliminate heat, redness and swelling caused by local non-infectious inflammation, thereby reducing the performance of inflammation, anti-inflammatory effect of this product 0.3mg is equal to dexamethasone 0.75mg, prednisone 5mg or 25mg cortisone . Betamethasone sodium retention effect is a hundred times more than hydrocortisone, in primary adrenal hypofunction, it can be used together with glucocorticoid for replacement therapy ,and it is used for preventing or inhibiting cell-mediated immune response, delaying allergic reactions and reducing the primary immune response expansion ,it is used for low renin and low aldosterone syndrome and autonomic neuropathy induced orthostatic hypotension. Currently betamethasone is also used for the treatment of active rheumatoid arthritis, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, acute leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, and pruritus and comprehensive treatment of certain infections. The product is contraindicated in severe psychiatric history, active duodenal ulcer, recent gastrointestinal anastomosis, heavier osteoporosis, overt diabetes, severe hypertension, virus , bacterial, fungal infections which are failed to control by the use of antimicrobial agents , thrombophlebitis, skin infections, such as impetigo, tinea, jock itch and so on. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | White crystalline powder. Mp 231-234 deg.] C (decomposition). Odorless. Acetate Betamethasone ([987-24-6]) is also white crystalline powder, melting point 205-208 ℃, slightly soluble in alcohol, ethanol, and very slightly soluble in chloroform or ether, insoluble in water, odorless. |
| Application | Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects. |
| production method | According to U.S. Patent No. 3,164,618, betamethasone acetate is dealt with hydrochloric acid in methanol - chloroform - water mixture , it can be converted to betamethasone. |
| Category | Toxic substances |
| Toxicity grading | Middle toxic |
| Acute toxicity | Oral -mouse LD50:> 4500 mg / kg |
| Flammability and hazard characteristics | Combustible;Its combustion produces toxic fumes of fluoride. |
| Storage Characteristics | Ventilated, low-temperature ,dry storeroom. |
| Extinguishing agent | Dry powder , foam, sand, carbon dioxide, water spray. |
| Chemical Properties | White to Off-White Solid |
| Usage | glucocorticoid, antiinflammatory |
| Usage | Betamethasone is a glucocorticoid used as an anti-inflammatory agent. |
| Usage | anti-inflammatory, immunosuppressive |
| Betamethasone Preparation Products And Raw materials |
| Raw materials | Betamethasone 21-acetate |
| Product Name: | Betamethasone |
| Synonyms: | (11beta,16beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;16-beta-methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20;16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione;17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-9-alpha-fluoro-11-bet;6beta)-;9-alpha-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione;9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-beta-methylpregna-1,4-diene;9-alpha-fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20 |
| CAS: | 378-44-9 |
| MF: | C22H29FO5 |
| MW: | 392.46 |
| EINECS: | 206-825-4 |
| Product Categories: | Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;Pharmaceutical intermediate;CELESTONE |
| Mol File: | 378-44-9.mol |
|
|
|
| Betamethasone Chemical Properties |
| mp | 235-237°C |
| refractive index | 118 ° (C=1, Dioxane) |
| storage temp. | 0-6°C |
| Merck | 1180 |
| CAS DataBase Reference | 378-44-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-(378-44-9) |
| Safety Information |
| Hazard Codes | Xi,Xn,T |
| Risk Statements | 40-48/20/21-61 |
| Safety Statements | 22-36-45-53 |
| RTECS | TU4000000 |
| HS Code | 29379000 |
| Hazardous Substances Data | 378-44-9(Hazardous Substances Data) |
| Betamethasone Usage And Synthesis |
| hormone drugs |
Betamethasone, belongs to adrenal corticosteroids, it is a isomer of dexamethasone , and the role of betamethasone is similiar to prednisolone and dexamethasone , it has anti-inflammatory, anti-rheumatic, anti-allergic and suppression of the immune and other pharmacological effects, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone etc. , it can reduce and prevent tissue response to inflammation and eliminate heat, redness and swelling caused by local non-infectious inflammation, thereby reducing the performance of inflammation, anti-inflammatory effect of this product 0.3mg is equal to dexamethasone 0.75mg, prednisone 5mg or 25mg cortisone . Betamethasone sodium retention effect is a hundred times more than hydrocortisone, in primary adrenal hypofunction, it can be used together with glucocorticoid for replacement therapy ,and it is used for preventing or inhibiting cell-mediated immune response, delaying allergic reactions and reducing the primary immune response expansion ,it is used for low renin and low aldosterone syndrome and autonomic neuropathy induced orthostatic hypotension. Currently betamethasone is also used for the treatment of active rheumatoid arthritis, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, acute leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, and pruritus and comprehensive treatment of certain infections. The product is contraindicated in severe psychiatric history, active duodenal ulcer, recent gastrointestinal anastomosis, heavier osteoporosis, overt diabetes, severe hypertension, virus , bacterial, fungal infections which are failed to control by the use of antimicrobial agents , thrombophlebitis, skin infections, such as impetigo, tinea, jock itch and so on. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | White crystalline powder. Mp 231-234 deg.] C (decomposition). Odorless. Acetate Betamethasone ([987-24-6]) is also white crystalline powder, melting point 205-208 ℃, slightly soluble in alcohol, ethanol, and very slightly soluble in chloroform or ether, insoluble in water, odorless. |
| Application | Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects. |
| production method | According to U.S. Patent No. 3,164,618, betamethasone acetate is dealt with hydrochloric acid in methanol - chloroform - water mixture , it can be converted to betamethasone. |
| Category | Toxic substances |
| Toxicity grading | Middle toxic |
| Acute toxicity | Oral -mouse LD50:> 4500 mg / kg |
| Flammability and hazard characteristics | Combustible;Its combustion produces toxic fumes of fluoride. |
| Storage Characteristics | Ventilated, low-temperature ,dry storeroom. |
| Extinguishing agent | Dry powder , foam, sand, carbon dioxide, water spray. |
| Chemical Properties | White to Off-White Solid |
| Usage | glucocorticoid, antiinflammatory |
| Usage | Betamethasone is a glucocorticoid used as an anti-inflammatory agent. |
| Usage | anti-inflammatory, immunosuppressive |
| Betamethasone Preparation Products And Raw materials |
| Raw materials | Betamethasone 21-acetate |