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CAS NO.362-07-2
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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| Product Name: | 2-METHOXYESTRADIOL |
| Synonyms: | 2,3,17BETA-TRIHYDROXY-1,3,5[10]-ESTRATRIENE 2-METHYL ETHER;3,17BETA-DIHYDROXY-2-METHOXY-1,3,5[10]-ESTRATRIENE;2-METHOXY-3,17BETA-DIHYDROXYESTRA-1,3,5(10)-TRIENE;2-METHOXY-ESTRA-1,3,5(10)-TRIENE-3,17BETA-DIOL;2-METHOXYESTRADIOL;1,3,5(10)-ESTRATRIENE-2,3,17BETA-TRIOL 2-METHYL ETHER;1,3,5[10]-ESTRATRIENE-2,3,17-TRIOL 2-METHYL ETHER;1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER |
| CAS: | 362-07-2 |
| MF: | C19H26O3 |
| MW: | 302.41 |
| EINECS: | |
| Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;Inhibitor;2-ME2;Isolabel;Inhibitors |
| Mol File: | 362-07-2.mol |
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| 2-METHOXYESTRADIOL Chemical Properties |
| mp | 188-190°C |
| storage temp. | −20°C |
| solubility | DMSO: 10 mg/mL |
| form | crystalline |
| color | light yellow |
| CAS DataBase Reference | 362-07-2(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T,Xi,N |
| Risk Statements | 23/24/25-36/37/38-48-61-60-46-45-51/53 |
| Safety Statements | 22-26-36/37/39-45-53-36-61 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | KG7537500 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| 2-METHOXYESTRADIOL Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Usage | A natural metabolite of 17 Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a |
| Usage | A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly |
| Usage | 2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity. |
| Usage | 2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2. |
| Usage | 2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function. |
| Biological Activity | Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly. |
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2-METHOXYESTRADIOL Preparation Products And Raw materials |