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CAS NO.31282-04-9
| Hygromycin B Basic information |
| Product Name: | Hygromycin B |
| Synonyms: | HYGROMYCIN B HYDRATE;HYGROMYCIN B, STREPTOMYCES HYGROSCOPICUS;HYGROMYCIN B, STREPTOMYCES SPECIES;HYGROGOLD(TM);O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTOHEPTAPYRANOSYLIDENE-(1,2,3)-O-BETA-D-TALOPYRANOSYL-(1,5)-2-DEOXY-N3-METHYL-D-STREPTAMINE;o-6-amino-6-deoxy-l-glycero-d-galacto-heptopyranosylidene-(1-2-3)-o-beta-d-talopyranosyl-(1-5)-2-deoxy-n3-methyl-d-streptamine;O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTO-HEPTOPYRANOSYLIDENE-(1-2-3)-O-BETA-D-TALOPYRANOSYL(1-5)-2-DEOXY-N3-METHYL-D-STREPTAMINE;)-o-beta-d-talopyranosyl-(1-5)-2-deoxy-n-(sup3)-methyl- |
| CAS: | 31282-04-9 |
| MF: | C20H37N3O13 |
| MW: | 527.52 |
| EINECS: | 250-545-5 |
| Product Categories: | antibiotic;Inhibitors |
| Mol File: | 31282-04-9.mol |
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| Hygromycin B Chemical Properties |
| Melting point | 160-180°C |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days. |
| form | powder |
| Merck | 13,4878 |
| Safety Information |
| Hazard Codes | T+,Xn,T |
| Risk Statements | 26/27/28-41-42/43-40-36-23/24/25 |
| Safety Statements | 23-26-28-36/37/39-45-22-36-36/37 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | WK2130000 |
| F | 19 |
| Hygromycin B Usage And Synthesis |
| Usage | antibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg |
| Usage | Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome |
| Usage | Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib osome |
| Usage | Hygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2. |
| General Description | Amorphous solid or tan powder. |
| Air & Water Reactions | Water soluble. |
| Reactivity Profile | Weakly basic. |
| Fire Hazard | Flash point data for Hygromycin B are not available; however Hygromycin B is probably combustible. |
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