HENAN SUNLAKE ENTERPRISE CORPORATION
Free supplier Enterprise Certification
- Free
supplier - 9th
years
Free supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
MaxCard:
Contact Suppliers
CAS NO.26807-65-8
1(10-100)Gram1(100-200)Gram
| Indapamide Basic information |
| Product Name: | Indapamide |
| Synonyms: | N-(4-CHLORO-3-SULFAMOYLBENZAMIDO)-2-METHYLINDOLINE;N-[4-CHLORO-3-SULFAMOYL-BENZAMIDOL]-2-METHYLINDOLINE;INDAPAMIDE;1-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline;3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-benzamid;3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)benzamide;4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoyl-benzamid;4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide |
| CAS: | 26807-65-8 |
| MF: | C16H16ClN3O3S |
| MW: | 365.83 |
| EINECS: | 248-012-7 |
| Product Categories: | Drug bulk;Cardiovascular;Active Pharmaceutical Ingredients;Organics;API;Cnbio;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Heterocycles;Indole Derivatives;Sulfur & Selenium Compounds;Heterocycle-Indole series;LOZOL;Other APIs |
| Mol File: | 26807-65-8.mol |
|
|
|
| Indapamide Chemical Properties |
| mp | 160-162°C |
| storage temp. | -20°C Freezer |
| CAS DataBase Reference | 26807-65-8(CAS DataBase Reference) |
| Safety Information |
| WGK Germany | 2 |
| RTECS | CV2451200 |
| MSDS Information |
| Provider | Language |
|---|---|
| N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline | English |
| SigmaAldrich | English |
| Indapamide Usage And Synthesis |
| Diuretic antihypertensive drug |
White needle crystal or crystalline powder, odorless, tasteless. It is almost insoluble in water or dilute hydrochloric acid, while it can be dissolved in ethanol or ethyl acetate, and it is soluble in acetone, acetic acid, slightly soluble in chloroform or ether. Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc. It was originally developed for the first time by the French Servier (Servier) pharmaceutical company. Indapamide film-coated tablets were first successfully developed by Tianjin Lisheng pharmaceutical company in 1988 in China. The trade name is "life than the mountains." In the mid-1990s, Zhejiang Apeloa pharmaceutical, Yantai Xiyuan pharmaceutical factory, Zhejiang East medicine, Dongguan million into pharmaceuticals, Shanxi Asia-medicine, medicine Fuxin Shibata, Puyang the yuan Pharmaceutical, Chongqing Friends of pharmaceutical drugs, 8 pharmaceutical formulations were approved for production. In the late 1990s, the French pharmaceutical company Servier took indapamide sustained-release tablets into China. The trade name is "Na Ionizers." Subsequently, indapamide raw material drug localization has been progress. Currently, seven companies have been allowed to produce raw material drug types. Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect. It can lower blood pressure with lower dose compared to diuretic effect. Higher dose will display diuretic effect. But there is no disadvantage compared to thiazide diuretics, that it does not cause orthostatic hypotension, flushing and reflex tachycardia, nor blood lipids, glucose metabolism and renal function. The therapeutic dosage for heart rate, cardiac output, electrocardiogram are no significant change, as well as for the central nervous system and autonomic. There is antihypertensive effect by oral for 2~3h, maintaining 24h. single medication has good effect. Diuretic effect appears at 3h, achieving maximum effect for 4~6h. It is different from other diuretics. This product is fat-soluble. After oral administration, there is highest concentration in the liver, renal plasma, and lower concentration in heart, lung, muscle, fat. This product excretes from the kidney mainly by metabolites and 5% of the prototype. Indapamide is for mild to moderate hypertension, and for sodium retention caused by congestive heart failure. It is also applied to hypertension with renal failure, diabetes mellitus, high blood lipids. Single medication has significant effect. It is combined with β-receptor blockers that has better effect. Because the drug has a diuretic effect, it can cause hypokalemia, which can add potassium. The above information is edited by the chemicalbook of Kui Ming. |
| Applications | For the treatment of mild to moderate essential hypertension. |
| Category toxic | Substances |
| Toxicity grading | Medium toxicity |
| Acute toxicity | Oral - rat LD50:> 3000 mg / kg; Oral - mouse LD50:> 3000 mg / kg. |
| Flammability hazard characteristics | Combustible; combustion produces toxic nitrogen oxides, sulfur oxides and chlorides smoke. |
| Storage characteristics | Treasury ventilation low-temperature drying. |
| Extinguishing agent | Dry powder, foam, sand, carbon dioxide, water mist. |
| Chemical Properties | Crystalline Solid |
| Usage | Used as an antihypertensive. Diuretic |
| Usage | diuretic, antihypertensive |
Service we provide:
1. Mixed container, we can mix different items in one container.
2. Quality control, before shipment, free sample for test. after shipment, keep sample for 3 years
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
We have clients throughout the world：
Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.
Our Laboratoy
We have our own independent lab test center：
This makes sure that our technology support is reliable and authoritative.All of self-owned fine chemicals are manufactured strictly in accordance with international standard.,and also has scientific cooperation with local colleges and institutes.
Our factory
High quality with competitive price：
We are manufacturer and can provide high quality products with factory price
Package & Shipment
Fast and safe delivery：
Parcels can be sent out within 24 hours after payment. Tracking number is available
Secure and discreet shipment. You have various choices of transportation methods
