HENAN SUNLAKE ENTERPRISE CORPORATION
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Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
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CAS NO.2627-69-2
| AICAR Basic information |
| adenosine regulating agents |
| Product Name: | AICAR |
| Synonyms: | ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE |
| CAS: | 2627-69-2 |
| MF: | C9H14N4O5 |
| MW: | 258.23 |
| EINECS: | 220-097-5 |
| Product Categories: | Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR |
| Mol File: | 2627-69-2.mol |
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| AICAR Chemical Properties |
| mp | 214-215 °C |
| storage temp. | −20°C |
| solubility | H2O: >10 mg/mL |
| form | powder |
| color | tan |
| CAS DataBase Reference | 2627-69-2(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2) |
| Safety Information |
| Hazard Codes | Xi,T |
| Risk Statements | 36/37/38-61 |
| Safety Statements | 26-36-45-53 |
| WGK Germany | 3 |
| AICAR Usage And Synthesis |
| enosine regulating agents |
Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death. |
| Chemical Properties | Solid |
| Usage | glucose uptake stimulant; AMPK activator |
| Usage | AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. |
| Biological Activity | Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. |
FQA
Q1: Can i get some samples A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, or Paypal or Escrow(Alibaba).
Q3: How to confirm the Product Quality before placing orders A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What’s your MOQ A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery leadtime A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6:Is there a discount A:Different quantity has different discount.
Q7: How do you treat quality complaint A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8: How to contact us
You can chat with us by Trademanager,MSN&Skype Online.
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