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Doxorubicin hydrochloride

CAS NO.25316-40-9

  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,Other
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Product Details

Keywords

  • ADRIACIN
  • ADRIBLASTINA
  • ADRIBLASTINA HYDROCHLORIDE

Quick Details

  • ProName: Doxorubicin hydrochloride
  • CasNo: 25316-40-9
  • Molecular Formula: C27H30ClNO11
  • Appearance: Orange-Red Crystalline Solid
  • Application: 25316-40-9
  • DeliveryTime: 7-10days after payment
  • PackAge: as customer's requirement
  • Port: China main port
  • ProductionCapacity: 100-200 Kilogram/Month
  • Purity: 99%
  • Storage: 2-8°C
  • Transportation: air or sea express
  • LimitNum: 1 Kilogram

Superiority

Product Name: Doxorubicin hydrochloride
Synonyms: ADRIACIN;ADRIBLASTINA;ADRIBLASTINA HYDROCHLORIDE;ADRIAMYCIN HCL;ADRIAMYCIN HYDROCHLORIDE;(8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;14-HYDROXYDAUNOMYCIN HCL;14-HYDROXYDAUNOMYCIN HYDROCHLORIDE
CAS: 25316-40-9
MF: C27H30ClNO11
MW: 579.98
EINECS: 246-818-3
Product Categories: APIs;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Adriamycin;inhibitor;Anti-cancer&immunity;Inhibitors
Mol File: 25316-40-9.mol
Doxorubicin hydrochloride Structure
 
Doxorubicin hydrochloride Chemical Properties
mp  216 °C (dec.)(lit.)
storage temp.  2-8°C
solubility  H2O: 10 mg/mL, clear, red-orange
Merck  13,3473
CAS DataBase Reference 25316-40-9(CAS DataBase Reference)
EPA Substance Registry System 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-. alpha.-L-lyxo-hexopyranosyl) oxy]-7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-(25316-40-9)
 
Safety Information
Hazard Codes  T,T+,Xi
Risk Statements  45-22-40-26/27/28-36/38
Safety Statements  53-45-36/37/39-22-7/9
WGK Germany  3
RTECS  QI9295900
F  10-21
 
Doxorubicin hydrochloride Usage And Synthesis
Chemical Properties Orange-Red Crystalline Solid
Usage Used as an antineoplastic
Usage Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
Usage Antibacterial;DNA intercalant
Usage Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
Usage Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumor agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
General Description Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9.
Air & Water Reactions Water soluble.
Reactivity Profile Amines, like Doxorubicin hydrochloride, are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard Doxorubicin hydrochloride is probably combustible.
Biological Activity Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.
 
Doxorubicin hydrochloride Preparation Products And Raw materials
Preparation Products Pirarubicin
Raw materials Daunorubicin
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
6.Packing pictures and loading video before loading
7.Free Sample
9.Factory audit
10.Strong after-sale service

Our Services
1. Quality control, before shipment, free sample for test.
2. Prompt shipment with professional documents
3. Packing as your request, with photo before shipment
4. We can provide mixed containers with different mixed items in one container
 
HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
     Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.
    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.
    We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.
     We  welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

 

 

 

 

 

Details

 
Product Name: Doxorubicin hydrochloride
Synonyms: ADRIACIN;ADRIBLASTINA;ADRIBLASTINA HYDROCHLORIDE;ADRIAMYCIN HCL;ADRIAMYCIN HYDROCHLORIDE;(8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;14-HYDROXYDAUNOMYCIN HCL;14-HYDROXYDAUNOMYCIN HYDROCHLORIDE
CAS: 25316-40-9
MF: C27H30ClNO11
MW: 579.98
EINECS: 246-818-3
Product Categories: APIs;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Adriamycin;inhibitor;Anti-cancer&immunity;Inhibitors
Mol File: 25316-40-9.mol
Doxorubicin hydrochloride Structure
 
Doxorubicin hydrochloride Chemical Properties
mp  216 °C (dec.)(lit.)
storage temp.  2-8°C
solubility  H2O: 10 mg/mL, clear, red-orange
Merck  13,3473
CAS DataBase Reference 25316-40-9(CAS DataBase Reference)
EPA Substance Registry System 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-. alpha.-L-lyxo-hexopyranosyl) oxy]-7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-(25316-40-9)
 
Safety Information
Hazard Codes  T,T+,Xi
Risk Statements  45-22-40-26/27/28-36/38
Safety Statements  53-45-36/37/39-22-7/9
WGK Germany  3
RTECS  QI9295900
F  10-21
 
Doxorubicin hydrochloride Usage And Synthesis
Chemical Properties Orange-Red Crystalline Solid
Usage Used as an antineoplastic
Usage Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
Usage Antibacterial;DNA intercalant
Usage Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
Usage Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumor agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
General Description Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9.
Air & Water Reactions Water soluble.
Reactivity Profile Amines, like Doxorubicin hydrochloride, are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard Doxorubicin hydrochloride is probably combustible.
Biological Activity Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.
 
Doxorubicin hydrochloride Preparation Products And Raw materials
Preparation Products Pirarubicin
Raw materials Daunorubicin

 

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