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CAS NO.21679-14-1
1(10-100)Gram1(100-200)Gram
| Fludarabine Basic information |
| Product Name: | Fludarabine |
| Synonyms: | 2-Fluoroadeninearabinoside;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin;9-beta-d-arabinofuranosyl-2-fluoro-adenin;f-ara-a;6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE;9-bata-d-arabinofuranosyl-2-fluoroadenine;9-BETA-D-ARABINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE;9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE |
| CAS: | 21679-14-1 |
| MF: | C10H12FN5O4 |
| MW: | 285.23 |
| EINECS: | 244-525-5 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;API;F-ara-A, NSC 118218;Anti-cancer&immunity;Inhibitors |
| Mol File: | 21679-14-1.mol |
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| Fludarabine Chemical Properties |
| mp | 265-268°C |
| storage temp. | 2-8°C |
| solubility | DMF: 20 mg/mL, clear, faintly yellow |
| Merck | 13,4152 |
| CAS DataBase Reference | 21679-14-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 23/24/25-36/37/38-39/23/24/25-39-22 |
| Safety Statements | 26-36/37-45 |
| WGK Germany | 3 |
| RTECS | AU6207000 |
| F | 10 |
| Hazardous Substances Data | 21679-14-1(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 9-bata-D-Arabinofuranosyl-2-fluoroadenine | English |
| SigmaAldrich | English |
| Fludarabine Usage And Synthesis |
| Chemical Properties | White Solid |
| Usage | Used as an antineoplastic |
| Usage | A STAT-1 activation inhibitor and a DNA synthesis inhibitor. |
| Usage | phosphate as antineoplastic;inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase |
| Usage | Irreversible muscarinic agonist |
| Usage | DNA synthesis and methylation inhibitor;A cell permeable agent that interferes with DNA synthesis and repair; also inhibits RNA transcription |
| Biological Activity | Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo . |
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