HENAN SUNLAKE ENTERPRISE CORPORATION
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Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
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| DAPT Basic information |
| Product Name: | DAPT |
| Synonyms: | LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;γ-Secretase Inhibitor IX;N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester;SC-201315;(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester;DAPT (enzyme inhibitor);GSI-IX;DAPT (GSI-IX) |
| CAS: | 208255-80-5 |
| MF: | C23H26F2N2O4 |
| MW: | 432.464 |
| EINECS: | |
| Product Categories: | Angiogenesis and Metastasis;Protease inhibitor;Inhibitor;GSI-IX;Inhibitors |
| Mol File: | 208255-80-5.mol |
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| DAPT Chemical Properties |
| density | 1.213 |
| storage temp. | 2-8°C |
| solubility | DMSO: ~18 mg/mL |
| form | solid |
| color | white |
| Safety Information |
| WGK Germany | 3 |
| DAPT Usage And Synthesis |
| Usage | DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells |
| Biological Activity | Inhibitor of γ -secretase; causes a reduction in A β 40 and A β 42 levels in human primary neuronal cultures (IC 50 values are 115 and 200 nM for total A β and A β 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . Does not effect APP α and APP β levels. Blocks Notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation. |
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Our Laboratoy
We have our own independent lab test center：
This makes sure that our technology support is reliable and authoritative.All of self-owned fine chemicals are manufactured strictly in accordance with international standard.,and also has scientific cooperation with local colleges and institutes.
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Parcels can be sent out within 24 hours after payment. Tracking number is available
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