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CAS NO.2062-78-4
| PIMOZIDE Basic information |
| Product Name: | PIMOZIDE |
| Synonyms: | PIMOZIDE;1-(1-(4,4-bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinon;1-(1-(4,4-bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone;1-(4,4-bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine;mcn-jr-6238;orap;1-[1-(4,4-BIS[4-FLUOROPHENYL]BUTYL)-4-PIPERIDINYL]-1,3-DIHYDRO-2H-BENZ-IMIDAZOL-2-ONE;3-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidyl)-1H-benzimidazol-2-one |
| CAS: | 2062-78-4 |
| MF: | C28H29F2N3O |
| MW: | 461.55 |
| EINECS: | 218-171-7 |
| Product Categories: | Organics;Dopamine receptor;ORAP;Inhibitors |
| Mol File: | 2062-78-4.mol |
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| PIMOZIDE Chemical Properties |
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL |
| CAS DataBase Reference | 2062-78-4(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | DE1750000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| PIMOZIDE Usage And Synthesis |
| Usage | antipsychotic |
| Usage | Used for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond satisfactorily to standard treatment. |
| Definition | ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophen l)butyl group. |
| Biological Activity | Dopamine D 2 -receptor antagonist and antipsychotic which binds with very high affinity to the cloned rat 5-HT 7 receptor (K i = 0.5 nM). |
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