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CAS NO.2016-88-8
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Preview |
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| Amiloride hydrochloride Basic information |
| Product Name: | Amiloride hydrochloride |
| Synonyms: | amiloridechloride;amiprazidine;n-amidino-3,5-diamino-6-chloro-pyrazinecarboxamidmonohydrochloride;N-AMIDINO-3,5-DIAMINO-6-CHLOROPYRAZINECARBOXAMIDE HYDROCHLORIDE;GUANAMPRAZINE;AMIPRAMIDIN;AMIPRAMIZIDE;AMILORIDE HCL |
| CAS: | 2016-88-8 |
| MF: | C6H8ClN7O.ClH |
| MW: | 266.09 |
| EINECS: | 217-958-2 |
| Product Categories: | Active Pharmaceutical Ingredients;Ion transporter and other ion channel;Ion Channels;Amines;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;MIDAMOR |
| Mol File: | 2016-88-8.mol |
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| Amiloride hydrochloride Chemical Properties |
| mp | 293-294°C |
| storage temp. | Store at RT |
| solubility | H2O: 50 mg/mL, clear, yellow-green |
| form | powder |
| color | yellow |
| Water Solubility | <0.1 g/100 mL at 19.5 ºC |
| CAS DataBase Reference | 2016-88-8(CAS DataBase Reference) |
| EPA Substance Registry System | Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)- 6-chloro-, monohydrochloride(2016-88-8) |
| Safety Information |
| Hazard Codes | T,Xi |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 36-45-26 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UQ2275500 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29339980 |
| MSDS Information |
| Provider | Language |
|---|---|
| Amiloride hydrochloride | English |
| SigmaAldrich | English |
| Amiloride hydrochloride Usage And Synthesis |
| Chemical Properties | Pale Yellow Solid |
| Usage | Na+ channel inhibitor, diuretic |
| Usage | A calcium channel andsodium channel protein inhibitor |
| Usage | Sodium channel blocker. Diuretic. |
| General Description | Crystalline solid or very light yellow powder. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | A halogenated amine and amide, acidic salt. In aqueous solution, behaves as a weak acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
| Health Hazard | SYMPTOMS: Symptoms of exposure to Amiloride hydrochloride include headache, weakness, fatigue, back, chest, neck, shoulder or extremity pain; nausea, anorexia, vomiting, abdominal pain, hyperkalemia, paresthesias, shock, dizziness, coughing, shortness of breath, depression, nervousness, flaccid paralysis of the extremities, bradycardia, flatulence, skin rash, gas pain, constipation and dyspnea. |
| Fire Hazard | Flash point data for Amiloride hydrochloride are not available; however, Amiloride hydrochloride is probably combustible. |
| Biological Activity | Na + channel blocker. Defines the I 2A -amiloride sensitive and I 2B -amiloride insensitive imidazoline binding sites. Also inhibits TRPP3 channels. |
| Amiloride hydrochloride Preparation Products And Raw materials |
| Raw materials | Ethyl cyanoacetate-->Glyoxal-->Guanidine hydrochloride |