HENAN SUNLAKE ENTERPRISE CORPORATION
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China (Mainland)
Business Type:Trading Company
Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
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CAS NO.163222-33-1
HENAN SUNLAKE ENTERPRISE CORPORATION
Our company advantages:
1、The highest quality with the competitive price.
2、Professional human services.
3、The fastest and safest delivery service.
4、The faster and safest delivery service.
5、The high purity products.
6、We have a sufficient supply of stock.
7、A variety of payments, such as L/C, TT, , MoneyGram or other payments.
Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others. These products have been being well exported to europe, southeast Asia, the Middle East ,Africa, South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team. We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market.
We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
Ezetimibe Basic information
| Cholesterol-lowering drugs |
| Product Name: | Ezetimibe |
| Synonyms: | 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one;EZETIMIBE;ZETIA;Ezitimibe∬EzetimibeC24H21F2N03;(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone, Sch-58235;1-(4-Flurophenyl)-(3R)-3-(4-flurophenyl)-(3S)-hydroxypropyl-(4S)-(4-hydroxyphenyl)-2-azetidinone;Ezetimide |
| CAS: | 163222-33-1 |
| MF: | C24H21F2NO3 |
| MW: | 409.43 |
| EINECS: | |
| Product Categories: | All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Final material;API;Isotope;CEDAX;Cardiovascular APIs;Ezetimibe |
| Mol File: | 163222-33-1.mol |
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| Ezetimibe Chemical Properties |
| mp | 164-166°C |
| storage temp. | -20 C Freezer |
| CAS DataBase Reference | 163222-33-1(CAS DataBase Reference) |
| Ezetimibe Usage And Synthesis |
| Cholesterol-lowering drugs |
Ezetimibe,jointly developed by Schering-Plough and Merck companies ,is the first selective cholesterol absorption inhibitor, the product is first approved by the US FDA listed as selective cholesterol absorption inhibitor class of drugs. Trade name is"EZETROL". Ezetimibe is a new selective cholesterol absorption inhibitor, it is also the first selective inhibitor of intestinal cholesterol absorption, and its mechanism of action is different from other lipid-lowering agents (such as: statins, bile acid sequestrants, phenoxy acid derivative thereof cattle and plant sterol ester compound), the product ,through binding with the intestinal brush border membrane vesicle membrane protein (relative molecular mass 145X103), inhibits intestinal absorption of cholesterol which is from diet and transported to the intestine via the bile tract , reduces serum and liver cholesterol. Different from acid chelating agent ,ezetimibe does not affect cholesterol esters, other steroids (such as bezoar acid), triglycerides and fat-soluble vitamin absorption. Its pharmacological effects have nothing to do with acetyl coenzyme A- cholesterol acetyltransferase (ACAT) inhibiting and LDL receptors (scavenger receptor) expression . After being absorbed in the liver , ezetimibe combined with glucuronic acid by enterohepatic circulation,is almost specifically targeting to the small intestine mucosa. It can be used alone or in combination with HMG-CoA reductase inhibitors (statins) jointly applied to the treatment of primary (heterozygous familial and non-familial) hypercholesterolemia, homozygous familial hypercholesterolemia (HoFH) homozygous sitosterol hyperlipidemia (hyperlipidemia or phytosterols). The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | White Solid |
| Usage | An antihyperlipoproteinemic. A Cholesterol absorption inhibitor |
| Usage | antibacterial |
| Usage | A cholesterol transport inhibitor that binds to NPC1L1 |
| Usage | For use as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia. |