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CAS NO.140-64-7
| Pentamidine isethionate Basic information |
| Product Name: | Pentamidine isethionate |
| Synonyms: | 1,5-BIS(P-AMIDINOPHENOXY)PENTANE BIS(2-HYDROXYETHANESULFONATE SALT);1,5-BIS[P-AMIDINOPHENOXY]PENTANE BIS[2-HYDROXYETHANESULFONATE SALT] ISETHIONATE SALT;4,4'-(PENTAMETHYLENEDIOXY)DIBENZAMIDE BIS(2-HYDROXYETHANESULFONATE);4,4'-(PENTAMETHYLENEDIOXY)DIBENZAMIDINE, BIS-2-HYDROXYETHANESULFONATE;PENTAMIDINE ISETHIONATE;PENTAMIDINE ISETHIONATE SALT;4,4'-(pentamethylenedioxy)dibenzamidine bis(2-hyd;pentamidine isetionate |
| CAS: | 140-64-7 |
| MF: | C23H36N4O10S2 |
| MW: | 592.68 |
| EINECS: | 205-424-1 |
| Product Categories: | API;HIV/AIDS/Related Products;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 140-64-7.mol |
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| Pentamidine isethionate Chemical Properties |
| mp | 188-194 °C(lit.) |
| storage temp. | −20°C |
| form | powder |
| Merck | 13,7192 |
| CAS DataBase Reference | 140-64-7(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-[1,5-pentanediylbis( oxy)]bis[benzenecarboximidamide] (2:1)(140-64-7) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-43 |
| Safety Statements | 26-36/37 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | CV6500000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Pentamidine isethionate Usage And Synthesis |
| Usage | Has been widely used as a drug to treat protozoal diseases, such as malaria, amoebic dysentery and trypanosomiasis. It has also been shown to be effective for both prophylaxis of pneumocystic carinii pneumonia (PCC). |
| Usage | Antiparasitic |
| General Description | Odorless white or almost white crystals or powder. Odor also reported as a slight butyric odor. Very bitter taste. pH (5% aqueous solution) 4.5-6.5. |
| Air & Water Reactions | Hygroscopic. May be sensitive to prolonged exposure to air. Aqueous solutions deteriorate on storage. Water soluble. |
| Reactivity Profile | Can decompose on prolonged exposure to light. |
| Fire Hazard | Flash point data for Pentamidine isethionate are not available; however, Pentamidine isethionate is probably combustible. |
| Biological Activity | Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist. |
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