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Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
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MaxCard:
CAS NO.13909-09-6
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SEMUSTINE Basic information |
Product Name: | SEMUSTINE |
Synonyms: | N-[2-CHLOROETHYL]-N'-[4-METHYLCYCLOHEXYL]-N-NITROSOUREA;SEMUSTINE;1-(2-Chloroethyl)-1-([(4-methylcyclohexyl)amino]carbonyl)-2-oxohydrazine;1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-ure;1-(2-Chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea;1-(2-Chloroethyl)-3-(trans-4-methyl-cyclohexyl)-1-nitrosourea;ICIG 1110;icig1110 |
CAS: | 13909-09-6 |
MF: | C10H18ClN3O2 |
MW: | 247.72 |
EINECS: | |
Product Categories: | Building Blocks;Chemical Synthesis;Nitrogen Compounds;Nitroso Compounds;Organic Building Blocks;ATROMID |
Mol File: | 13909-09-6.mol |
SEMUSTINE Chemical Properties |
Safety Information |
Hazard Codes | T |
Risk Statements | 45-46-23/24/25-36/37/38 |
Safety Statements | 53-22-26-36/37/39-45 |
RIDADR | 3249 |
WGK Germany | 3 |
RTECS | YS5000000 |
HazardClass | 6.1(a) |
PackingGroup | II |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
SEMUSTINE Usage And Synthesis |
Usage | Commonly used in pharmacological studies involving: • ;Nutrient-sensitized screening for drugs that shift the energy metabolism from mitchondrial respiration to glycolysis1• ;CEOP regimen with semustine used as induction chemotherapy in patients with lymphoma2• ;Investigations into its use for chemotherapy3,4 |
Usage | antihyperlipidemic |
General Description | Light yellow powder. |
Air & Water Reactions | Insoluble in water. |
Reactivity Profile | A halogenated and nitrated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
Fire Hazard | Flash point data for SEMUSTINE are not available. SEMUSTINE is probably combustible. |
SEMUSTINE Preparation Products And Raw materials |