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CAS NO.13422-55-4
| Mecobalamin Basic information |
| Product Name: | Mecobalamin |
| Synonyms: | MECOBALAMIN;MECOBALAMINE;METHYLCOBALAMIN;cobalt-methylcobalamin;cobinamide,cobalt-methylderivative,hydroxide,dihydrogenphosphate(ester),;innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidazole;mbl-a;methycobal |
| CAS: | 13422-55-4 |
| MF: | C63H91CoN13O14P |
| MW: | 1344.38 |
| EINECS: | 236-535-3 |
| Product Categories: | PHARMACEUTICALS;Nutritional Supplements;Intermediates & Fine Chemicals;Vitamin B12;Nutrition Research;Vitamins;Vitamin Ingredients;API |
| Mol File: | 13422-55-4.mol |
|
|
|
| Mecobalamin Chemical Properties |
| mp | >190°C (dec.) |
| storage temp. | −20°C |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 2 |
| RTECS | GG3745000 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Mecobalamin Usage And Synthesis |
| Pharmacological action |
Mecobalamin as vitamin B12 derivatives, should be called "methyl vitamin B12" according to the chemical structure of name, the functional groups of methylation can be involved in the biochemical process of methyl transfer activity, promoting to nucleic acid of nerve tissue, the metabolism of protein and fat, , can stimulate the synthesis of lecithin Schwann cells, repairing the damaged myelin, improving nerve conduction velocity; directly into nerve cells, and stimulating axon regeneration of damaged area; stimulating protein synthesis in nerve cells and enhanced synthetic metabolism of axons to prevent axonal degeneration; involved in nucleic acid synthesis, promoted hematopoietic function. The treatment is clinically used in diabetic neuropathy, long-term use of macrovascular complications of diabetes are the curative effect. Mecobalamin is used for peripheral nerve disorders treatment drug, compared with other vitamin B12 preparations, having good transfer on the nervous tissue, through the methyl transfer reaction, can promote nucleic acid, protein lipid metabolism, repairing the damaged nerve tissue. In homocysteine synthetic egg ammonia acid process, it plays a role of coenzyme, especially by deoxyuridine synthesis of thymidine, promoting DNA and RNA synthesis of participation. Also in the experiment of glial cells, the drugs can improve methionine synthase activity and promote the synthesis of myelin lipids lecithin. Improving the nerve tissue metabolism, can promot axis cable and protein synthesis, make the delivery rate of the skeletal protein close to normal, maintain axonal functions. Besides mecobalamin injections can inhibit nerve tissue of abnormal impulse conduction, promoting redl blood cells mature, split, improving anemia. Mecobalamin can be quickly restored due to lack of B12 and reduce the number of rat erythrocytes, hemoglobin, hematocrit value. Used for megaloblastic red blood cell anemia and peripheral nerve disorder due to the lack of vitamin B12. The above information is edited by the Chemicalbook Hanya. |
| Application |
1.It is used for the treatment of nervous system diseases, relieving pain and numbness, speeded relieving pain, improving pain caused by cervical spondylosis, treatment of sudden deafness, etc. 2.Methylcobalamin is a kind of endogenous coenzyme B12, participating in the one carbon unit cycle, playing an important role in the synthesis of methionine homocysteine methyl transfer reaction process. |
| Chemical Properties | Dark Red Crystalline Powder |
| Usage | One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic). |
| Usage | Histamine receptor, Alzheimer research |
| Mecobalamin Preparation Products And Raw materials |
| Raw materials | Cyanocobalamin |
| Mecobalamin Basic information |
| Product Name: | Mecobalamin |
| Synonyms: | MECOBALAMIN;MECOBALAMINE;METHYLCOBALAMIN;cobalt-methylcobalamin;cobinamide,cobalt-methylderivative,hydroxide,dihydrogenphosphate(ester),;innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidazole;mbl-a;methycobal |
| CAS: | 13422-55-4 |
| MF: | C63H91CoN13O14P |
| MW: | 1344.38 |
| EINECS: | 236-535-3 |
| Product Categories: | PHARMACEUTICALS;Nutritional Supplements;Intermediates & Fine Chemicals;Vitamin B12;Nutrition Research;Vitamins;Vitamin Ingredients;API |
| Mol File: | 13422-55-4.mol |
|
|
|
| Mecobalamin Chemical Properties |
| mp | >190°C (dec.) |
| storage temp. | −20°C |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 2 |
| RTECS | GG3745000 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Mecobalamin Usage And Synthesis |
| Pharmacological action |
Mecobalamin as vitamin B12 derivatives, should be called "methyl vitamin B12" according to the chemical structure of name, the functional groups of methylation can be involved in the biochemical process of methyl transfer activity, promoting to nucleic acid of nerve tissue, the metabolism of protein and fat, , can stimulate the synthesis of lecithin Schwann cells, repairing the damaged myelin, improving nerve conduction velocity; directly into nerve cells, and stimulating axon regeneration of damaged area; stimulating protein synthesis in nerve cells and enhanced synthetic metabolism of axons to prevent axonal degeneration; involved in nucleic acid synthesis, promoted hematopoietic function. The treatment is clinically used in diabetic neuropathy, long-term use of macrovascular complications of diabetes are the curative effect. Mecobalamin is used for peripheral nerve disorders treatment drug, compared with other vitamin B12 preparations, having good transfer on the nervous tissue, through the methyl transfer reaction, can promote nucleic acid, protein lipid metabolism, repairing the damaged nerve tissue. In homocysteine synthetic egg ammonia acid process, it plays a role of coenzyme, especially by deoxyuridine synthesis of thymidine, promoting DNA and RNA synthesis of participation. Also in the experiment of glial cells, the drugs can improve methionine synthase activity and promote the synthesis of myelin lipids lecithin. Improving the nerve tissue metabolism, can promot axis cable and protein synthesis, make the delivery rate of the skeletal protein close to normal, maintain axonal functions. Besides mecobalamin injections can inhibit nerve tissue of abnormal impulse conduction, promoting redl blood cells mature, split, improving anemia. Mecobalamin can be quickly restored due to lack of B12 and reduce the number of rat erythrocytes, hemoglobin, hematocrit value. Used for megaloblastic red blood cell anemia and peripheral nerve disorder due to the lack of vitamin B12. The above information is edited by the Chemicalbook Hanya. |
| Application |
1.It is used for the treatment of nervous system diseases, relieving pain and numbness, speeded relieving pain, improving pain caused by cervical spondylosis, treatment of sudden deafness, etc. 2.Methylcobalamin is a kind of endogenous coenzyme B12, participating in the one carbon unit cycle, playing an important role in the synthesis of methionine homocysteine methyl transfer reaction process. |
| Chemical Properties | Dark Red Crystalline Powder |
| Usage | One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic). |
| Usage | Histamine receptor, Alzheimer research |
| Mecobalamin Preparation Products And Raw materials |
| Raw materials | Cyanocobalamin |