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CAS NO.127-07-1
Hydroxyurea Basic information |
Product Name: | Hydroxyurea |
Synonyms: | biosupressin;carbamohydroxamicacid;carbamohydroxyamicacid;Carbamoylhydroxylamine;carbamoyloxime;carbamylhydroxamate;hidrix;hu |
CAS: | 127-07-1 |
MF: | CH4N2O2 |
MW: | 76.05 |
EINECS: | 204-821-7 |
Product Categories: | Miscellaneous Biochemicals;pharmacetical;Aliphatics;Nucleotides and Nucleosides;Hydroxylamines;Hydroxylamines (N-Substituted);Bases & Related Reagents;Nitric Oxide Reagents;Nucleotides;Carbonyl Compounds;Organic Building Blocks;Ureas;DNA Synthesis Inhibitors;DNA Synthesis InhibitorsCancer Research;Antitumor Agents;Apoptosis and Cell Cycle;DNA metabolism;Aids Aided Treatment;Amines;HYDREA;proteinmod;Anti-cancer&immunity |
Mol File: | 127-07-1.mol |
Hydroxyurea Chemical Properties |
mp | 135-140 °C |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL |
form | powder |
color | white |
Water Solubility | soluble |
Merck | 14,4848 |
BRN | 1741548 |
CAS DataBase Reference | 127-07-1(CAS DataBase Reference) |
EPA Substance Registry System | Urea, hydroxy-(127-07-1) |
Safety Information |
Hazard Codes | T,Xn |
Risk Statements | 46-63-61-40 |
Safety Statements | 53-36/37-45-36-22 |
RIDADR | 2811 |
WGK Germany | 3 |
RTECS | YT4900000 |
Hazard Note | Toxic |
PackingGroup | III |
Hazardous Substances Data | 127-07-1(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
Hydroxyurea | English |
SigmaAldrich | English |
ACROS | English |
ALFA | English |
Hydroxyurea Usage And Synthesis |
Chemical Properties | Off-White Crystalline Solid |
Usage | An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. |
Usage | antineoplastic, inhibits ribonucleoside diphosphate reductase |
General Description | Odorless or almost odorless white to off-white crystalline solid. Tasteless. |
Air & Water Reactions | Water soluble. |
Reactivity Profile | An amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
Fire Hazard | Flash point data for Hydroxyurea are not available; however, Hydroxyurea is probably combustible. |
Hydroxyurea Preparation Products And Raw materials |
Preparation Products | Linuron |
Raw materials | Urethane |
Hydroxyurea Basic information |
Product Name: | Hydroxyurea |
Synonyms: | biosupressin;carbamohydroxamicacid;carbamohydroxyamicacid;Carbamoylhydroxylamine;carbamoyloxime;carbamylhydroxamate;hidrix;hu |
CAS: | 127-07-1 |
MF: | CH4N2O2 |
MW: | 76.05 |
EINECS: | 204-821-7 |
Product Categories: | Miscellaneous Biochemicals;pharmacetical;Aliphatics;Nucleotides and Nucleosides;Hydroxylamines;Hydroxylamines (N-Substituted);Bases & Related Reagents;Nitric Oxide Reagents;Nucleotides;Carbonyl Compounds;Organic Building Blocks;Ureas;DNA Synthesis Inhibitors;DNA Synthesis InhibitorsCancer Research;Antitumor Agents;Apoptosis and Cell Cycle;DNA metabolism;Aids Aided Treatment;Amines;HYDREA;proteinmod;Anti-cancer&immunity |
Mol File: | 127-07-1.mol |
Hydroxyurea Chemical Properties |
mp | 135-140 °C |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL |
form | powder |
color | white |
Water Solubility | soluble |
Merck | 14,4848 |
BRN | 1741548 |
CAS DataBase Reference | 127-07-1(CAS DataBase Reference) |
EPA Substance Registry System | Urea, hydroxy-(127-07-1) |
Safety Information |
Hazard Codes | T,Xn |
Risk Statements | 46-63-61-40 |
Safety Statements | 53-36/37-45-36-22 |
RIDADR | 2811 |
WGK Germany | 3 |
RTECS | YT4900000 |
Hazard Note | Toxic |
PackingGroup | III |
Hazardous Substances Data | 127-07-1(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
Hydroxyurea | English |
SigmaAldrich | English |
ACROS | English |
ALFA | English |
Hydroxyurea Usage And Synthesis |
Chemical Properties | Off-White Crystalline Solid |
Usage | An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. |
Usage | antineoplastic, inhibits ribonucleoside diphosphate reductase |
General Description | Odorless or almost odorless white to off-white crystalline solid. Tasteless. |
Air & Water Reactions | Water soluble. |
Reactivity Profile | An amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
Fire Hazard | Flash point data for Hydroxyurea are not available; however, Hydroxyurea is probably combustible. |
Hydroxyurea Preparation Products And Raw materials |
Preparation Products | Linuron |
Raw materials | Urethane |