Keywords

• Cabozantinib Malate
• 1140909-48-3
• C32H30FN3O10

Quick Details

• ProName: Cabozantinib Malate
• CasNo: 1140909-48-3
• Molecular Formula: C32H30FN3O10
• Appearance: powder
• Application: 1140909-48-3
• DeliveryTime: within 3-7 days
• PackAge: as requested
• Port: China Main Port
• ProductionCapacity: 300 Kilogram/Month
• Purity: 98%
• Storage: store in cool, dry place
• Transportation: by sea or by air
• LimitNum: 1 Kilogram

Superiority

Cabozantinib Malate Basic information

Product Name:	Cabozantinib Malate
Synonyms:	(2S)-2-Hydroxybutanedioic acid compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1);Cabozantinib (S)-malate;Cabozantinib L-Malate Salt;N-[4-[(6,7-DiMethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxaMide (2S)-;Cabozantinib (S)-Malate(XL-184);Cabozantinib L-Malate;Cabozantinib Malate (XL184);XL-184 (Malate)
CAS:	1140909-48-3
MF:	C32H30FN3O10
MW:	635.5931032
EINECS:
Product Categories:	Inhibitors
Mol File:	1140909-48-3.mol

Cabozantinib Malate Chemical Properties

Safety Information

MSDS Information

 

Cabozantinib Malate Usage And Synthesis

Chemical Properties	Off-White Solid
Usage	Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell a poptosis.
Usage	XL184 (Cabozantinib, BMS-907351) is a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively.
Usage	Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.

Cabozantinib Malate Preparation Products And Raw materials

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