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Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
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CAS NO.107868-30-4
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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4. Mixed containers with different mixed items in one container
About Company
Product Name: | Exemestane |
Synonyms: | 6-methylenandrosta-1,4-diene-3,17-dione;6-METHYLENEANDROSTA-1,4-DIENE-3,17-DIONE;10,13-dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-;EXEMESTANE;FCE-24304;AROMASIN;Exemestan;Exemestance |
CAS: | 107868-30-4 |
MF: | C20H24O2 |
MW: | 296.4 |
EINECS: | |
Product Categories: | Active Pharmaceutical Ingredients;chiral;Antineoplastic (Hormonal);Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pfizer compounds;Steroid and Hormone;API;Anti-cancer&immunity;Inhibitors |
Mol File: | 107868-30-4.mol |
Exemestane Chemical Properties |
mp | 155.13°C |
storage temp. | Store at -20°C |
CAS DataBase Reference | 107868-30-4(CAS DataBase Reference) |
Safety Information |
Hazard Codes | T,N |
Risk Statements | 60-61-51 |
Safety Statements | 53-22-36/37-57 |
Hazardous Substances Data | 107868-30-4(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
10,13-Dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene- | English |
Chemical properties | White solid, melting point 190 ~ 192℃. |
Applications |
1.The second generation aromatase inhibitors, used for the treatment of metastatic breast cancer and used as adjuvant therapy for early breast cancer. 2.Pharmaceutical raw materials, is a kind of irreversible steroid body aromatase extinguishing agent, can inhibit the synthesis of estrogen, and reduce circulating estrogen levels, applicable to the progression of disease after treatment with tamoxifen in postmenopausal patients with advanced breast cancer. |
Producing method | Androst-4-ene-3, 17-dione (2) and triethyl orthoformate dissolved in tetrahydrofuran and anhydrous ethanol, reacting under the presence of p-toluenesulfonic acid, and then add into N-methyl aniline and formaldehyde solution to continue the reaction. The obtained Mannich reaction product dissolved in anhydrous benzoic acid and anhydrous two alkyl, under the action of DDQ, to get exemestane, and the total yield is 45%. |
Chemical Properties | white to light yellow crystal powder |
Usage | An antineoplastic (hormonal) |
Usage | antiinfective |
Usage | Labeled Exemestane, intended for use as an internal standard for the quantification of Exemestane by GC- or LC-mass spectrometry. |
Exemestane Preparation Products And Raw materials |
Raw materials | Etanol-->Tetrahydrofuran-->Formaldehyde-->p-Toluenesulfonic acid-->Benzoic acid |