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Tel: 17734809689
Tel: 86-371-86259723
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Tel: 17734809689
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Tel: +86-371- 86259723
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CAS NO.1001264-89-6
1(10-100)Metric Ton1(10-100)Metric Ton
| GDC-0068 Basic information |
| Product Name: | GDC-0068 |
| Synonyms: | GDC-0068;GDC-0068(RG7440);RG7440;(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone;Ipatasertib (GDC-0068);Ipatasertib;(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one;(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone Ipatasertib (GDC-0068) |
| CAS: | 1001264-89-6 |
| MF: | C24H32ClN5O2 |
| MW: | 457.99618 |
| EINECS: | |
| Product Categories: | Inhibitor;PI3K/Akt/mTOR;Inhibitors |
| Mol File: | 1001264-89-6.mol |
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| GDC-0068 Chemical Properties |
| density | 1.254 |
| Safety Information |
| GDC-0068 Usage And Synthesis |
| Usage | DC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2, and Akt3 with IC50 of 5 nM, 18 nM, and 8 nM, respectively. |
| Usage | (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1 , Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer. |
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